This section of the website provides a collection of useful information about solid phase
peptide synthesis (SPPS). Since the inception of SPPS by Bruce Merrifield in 1963 (JACS 85(14) p.
2149-54), this technique has been
used to create natural and non-natural molecules for the study of
biological and engineered systems.
FMOC-Amino Acid coupling mechanism . Proton shuffling is not included in this figure.
FMOC Deprotection Mechanism