Welcome to the Sussman Lab
Research in the Sussman lab at the University of Wisconsin-Madison Biotechnology Center focuses on two main goals: (1)
Development of novel technologies for global characterization
of biological systems, and (2) Application of traditional
genetics and biochemistry as well as novel technology to
better understand the role of plasma membrane proteins in
eukaryotic cell differentiation, with emphasis on the two
model eukaryotes, Arabidopsis and yeast.
Within the realm of technology development, the laboratory has previously
pioneered the development of a reverse genetic approach for
performing functional genomics in Arabidopsis, as well as the
development and use of new technologies for elucidating the
downstream signaling components of plasma membrane hormone
receptors. Transcriptome measurements using custom DNA tiling chips fabricated on a maskless array synthesizer (Nimblegen) have
identified clusters of genes whose changes in expression are
correlated with particular hormone response pathways initiated
at the plasma membrane. Since 1998, the Sussman laboratory has
been implementing various strategies for isotope-assisted mass
spectrometry-based techniques to monitor changes in protein
and metabolite expression as a compliment to the genomic
technologies.
Researchers in the Sussman lab work on a wide range of
projects within these broadly defined scopes. For more
information on specific research topics, see the Research page.